End-Stage Renal Disease (ESRD) is the final, irreversible stage of chronic kidney disease (CKD), where kidney function declines to less than 15% of normal capacity. Patients with ESRD require lifelong dialysis or a kidney transplant to survive. Accurate medical coding is crucial for proper diagnosis, treatment, and billing.
The ICD-10-CM code for ESRD is N18.6, but additional codes may be required to document complications, comorbidities, and treatment modalities. This guide provides an in-depth look at ESRD coding, including related conditions, billing best practices, and real-world examples to ensure compliance and accuracy.

icd 10 code for esrd
2. Understanding End-Stage Renal Disease (ESRD)
Definition and Causes
ESRD occurs when kidneys can no longer function independently, leading to dangerous levels of waste and fluid buildup in the body. Common causes include:
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Diabetes mellitus (leading cause)
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Hypertension
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Glomerulonephritis
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Polycystic kidney disease
Symptoms and Complications
Patients may experience:
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Severe fatigue
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Swelling (edema)
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Shortness of breath
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Confusion (uremic encephalopathy)
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Anemia (due to low erythropoietin production)
3. ICD-10 Coding System: An Overview
The International Classification of Diseases, 10th Revision (ICD-10) is a standardized system used for:
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Diagnosing diseases
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Tracking public health trends
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Processing insurance claims
Structure of ICD-10 Codes
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First character: Alphabetical (e.g., “N” for kidney diseases)
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Next two digits: Category (e.g., “18” for CKD)
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Decimal point followed by additional digits: Specifies severity and complications
4. ICD-10 Codes for ESRD
The primary code for ESRD is:
| Condition | ICD-10 Code | Description |
|---|---|---|
| ESRD | N18.6 | End-stage renal disease |
| ESRD on Dialysis | N18.6 + Z99.2 | ESRD requiring dialysis |
Related Codes
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Hypertensive kidney disease with ESRD: I12.0
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Diabetic CKD with ESRD: E11.22 (Type 2) or E10.22 (Type 1)
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ESRD with anemia: D63.1
5. Coding Guidelines for ESRD
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Documentation must specify ESRD (not just CKD stage 5).
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Sequence N18.6 as primary if ESRD is the reason for the encounter.
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Include Z99.2 if the patient is on dialysis.
6. Common Comorbidities and Their Codes
| Condition | ICD-10 Code |
|---|---|
| Hypertension with ESRD | I12.0 |
| Diabetes with ESRD | E11.22 (Type 2) |
| Anemia in CKD | D63.1 |
| Hyperkalemia | E87.5 |
7. ESRD Treatment Modalities and Their Codes
| Treatment | ICD-10 Code |
|---|---|
| Hemodialysis | Z99.2 |
| Peritoneal dialysis | Z99.2 |
| Kidney transplant status | Z94.0 |
8. Billing and Reimbursement Considerations
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Medicare ESRD Program covers dialysis and transplants.
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Common denials: Missing Z99.2 or incorrect sequencing.
9. Case Studies and Coding Examples
Case 1:
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Diagnosis: ESRD due to diabetes on hemodialysis.
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Codes: E11.22, N18.6, Z79.899 (insulin use), Z99.2.
Case 2:
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Diagnosis: ESRD with hypertension and anemia.
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Codes: I12.0, N18.6, D63.1.
10. Frequently Asked Questions (FAQs)
Q1: What is the difference between CKD stage 5 and ESRD?
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CKD stage 5 means kidney function is ≤15%, but ESRD is when dialysis or transplant is needed.
Q2: Can N18.6 be used alone?
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No, always include complications (e.g., hypertension, diabetes).
Q3: What is the code for a kidney transplant recipient?
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Z94.0 (Kidney transplant status), plus N18.6 if ESRD persists.
11. Conclusion
Accurate ICD-10 coding for ESRD ensures proper patient care and billing compliance. Always document ESRD (N18.6), related conditions, and treatment modalities. Follow Medicare guidelines to avoid claim denials and improve reimbursement accuracy.
